1. Therapeutic target identification and validation: the case of enzymes
In the therapeutic discovery phase, thousands of candidate molecules are analyzed to test their efficacy against a given target (drug screening). Of these, only several hundred will be retained for further preclinical development (optimization of synthesis, formulation (§
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Therapeutic target identification and validation: the case of enzymes
Bibliography
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(1) - SIMOENS (S.), HUYS (I.) -
R&D Costs of New Medicines: A Landscape Analysis.
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In Frontiers in Medicine, vol. 8, p. 760762 (2021) – 10.3389/fmed.2021.760762
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(2) - DIMASI (J.A.), GRABOWSKI (H.G.), HANSEN (R.W.) -...
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