Example of a sol-gel collagen-inspired hydrogel
Collagen-based biomaterials for health applications

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MED7150 V1 Article

Example of a sol-gel collagen-inspired hydrogel
Collagen-based biomaterials for health applications

Authors : Cécile ECHALIER, Ahmad MEHDI, Jean MARTINEZ, Gilles SUBRA

Publication date: May 10, 2018 | Lire en français

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4. Example of a sol-gel collagen-inspired hydrogel

At the University of Montpellier, researchers at the Institut des Biomolécules Max Mousseron and the Institut Charles Gerhardt have pooled their expertise to develop a new type of biomaterial that would combine the biocompatibility and bioactivity of natural polymers with the ease of synthesis and chemical modification of synthetic molecules. They naturally turned to collagen-mimicking peptides. Unlike the work presented in paragraph 3, their aim was not to reproduce the multi-scale structure of collagen, but rather to create a favorable three-dimensional environment for cells by repeatedly presenting them with Pro-Hyp-Gly motifs. Sol-gel chemistry was used to polymerize collagen peptides under mild conditions.

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