Pharmaceutical and biomedical applications
Industrial applications of supercritical fluids and implementation equipments

As the "positive" list of GRAS (Generally Recognized As Safe) solvents is constantly shrinking, there is keen interest in using supercritical CO₂ as a solvent for extraction, fractionation and, above all, formulation of pharmaceutical and dermocosmetic active ingredients.

First of all, when products for the pharmaceutical industry are produced, the equipment must be designed, operated, cleaned and maintained in accordance with strict standards for the protection of operators, the environment and the final product (GMP).

• Extraction

  Apart from the extraction of naturally-occurring active ingredients (cf. § 1.), known industrial applications are still limited, such as the desolvation of active ingredients (cephalosporin-class antibiotics) and the delipidation...