Respiratory irritation, eye irritation, skin irritation: how does the localized action of chemical substances affect the body? : How are eye irritation tests conducted?

How are eye irritation tests conducted?
Respiratory irritation, eye irritation, skin irritation: how does the localized action of chemical substances affect the body?

Author : Alain LOMBARD

Publication date: February 10, 2025 | Lire en français

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5. How are eye irritation tests conducted?

5.1 In vivo" test on albino rabbit eyes

OECD test no. 405: Acute irritant/corrosive effect on eyes.

Application of 0.1 g of product in the conjunctival cul-de-sac of one eye of three albino rabbits. The second eye served as a control.
Rating of the intensity of effects according to a scale (erythema and palpebral edema, congestion of the iris and corneal abrasion)

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How are eye irritation tests conducted?