Solvent-free synthesis
Chemistry without solvents

Solvents are generally inert liquids that dissolve reagents, allowing them to come into contact, interact and react. However, their influence in synthesis can be very important, as solvent-reagent and solvent-reaction intermediate interactions, through stabilization effects, very often control the outcome and efficiency of a chemical synthesis. These effects depend, of course, on the structure of the solvent (dielectric constant, possibility of establishing hydrogen bonds, etc.). .

In addition, the presence of a solvent makes it possible to control heat exchange during a reaction, both in the laboratory and on an industrial scale. In the case of heating, for example, the solvent can convey the energy required by the reaction...