1. The essential consequences of polymorphism in the pharmaceutical field
Previous articles
and
have already given a glimpse of the main consequences expected in the pharmaceutical sector.
They mainly concern :
dissolution kinetics and, possibly, bioavailability;
the manufacturability of the active ingredient and the finished product;
the stability of the latter two.
These areas have already been more or less developed, so we'll confine ourselves here to briefly touching on certain aspects.
Most drugs are still prescribed orally (tablets, capsules, suspensions,...
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The essential consequences of polymorphism in the pharmaceutical field
References
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(1) - ALI (A.A.), FAROUK (A.) -
Comparative studies on the bioavailability of ampicillin anhydrate and trihydrate
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. International Journal of Pharmaceutics, 9, p. 239-243 (1981).
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(2) - HILL (S.A.), JONES (K.H.), SEAGER (H.), TASKIS (C.B.) -
Dissolution...
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