Conclusion
Polymorphism; Basic principles and characterization methods

This article on crystalline polymorphism explores this complex process, from its physical origins to its thermodynamic aspects. The same primary structure of a molecule can crystallize in different forms, and the physical and chemical properties are likely to differ between two crystalline forms of a given molecule. This leads to differences in reactivity, which can have an impact on stability and shelf life, especially in the case of pharmaceutical products.

Crystalline polymorphism research methods have been developed, using various spectral, thermal or X-ray diffraction techniques. These are increasingly being replaced by robotized systems for high-throughput polymorphic screening