1. Observation modeling and curve estimation
Statistical analysis of immunoassay data involves modeling and estimating the parameters of a curve in a regression model. For this reason, the regression model and methods for estimating parameters are described in this first paragraph.
1.1 Estimation of a calibration curve. Interferon gamma assay
Interferon-gamma assays are used to diagnose patients suffering from severe mutations that seriously disrupt the functioning of their immune system. . Quantifying the gamma interferon contained in a plasma sample requires a two-step procedure:
establish a calibration curve from a standard solution;
invert the curve to determine the unknown dose of gamma interferon contained...
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Observation modeling and curve estimation
Precision estimators, confidence intervals and tests
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