Selection, construction and practical implementation of experimental design tests
Validation of the robustness of an analytical method by design of experiments

Among the plethora of experimental designs available, the Plackett-Burman (PB) design (Tool 1 ) has gained widespread acceptance. This type of matrix has the advantage of involving a relatively small number of experiments compared with the total number of factors usually studied. For example, 11 variables can be studied in 12 experiments using a PB design (ASTM E1169-14).

The roadmap defining all the experiments in the plan to be carried out is formalized in...