1. The essential consequences of polymorphism in the pharmaceutical field
Previous articles and have already given a glimpse of the main consequences expected in the pharmaceutical sector.
They mainly concern :
dissolution kinetics and, possibly, bioavailability;
the manufacturability of the active ingredient and the finished product;
the stability of the latter two.
These areas have already been more or less developed, so we'll confine ourselves here to briefly touching on certain aspects.
1.1 Polymorphism / dissolution kinetics and bioavailability
Most drugs are still prescribed orally (tablets, capsules, suspensions, oral solutions). Once in the stomach, the galenic form undergoes a process of disintegration, gradually releasing the active ingredient throughout the...
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The essential consequences of polymorphism in the pharmaceutical field
Some regulatory aspects of the pharmaceutical sector
References
- (1) - ALI (A.A.), FAROUK (A.) - Comparative studies on the bioavailability of ampicillin anhydrate and trihydrate - . International Journal of Pharmaceutics, 9, p. 239-243 (1981).
- (2) - HILL (S.A.), JONES (K.H.), SEAGER (H.), TASKIS (C.B.) - Dissolution and bioavailability of the anhydrate and trihydrate...
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