Conclusion
Organometallic Nucleophilic Reagents in Organic Synthesis. Theory and Applications

The use of organometallic nucleophilic reagents remains an effective and direct approach to the creation of carbon-carbon bonds. The range of substrates and products accessible by these methodologies is immense, which makes them very popular. As we have seen, organometallic compounds can be used either directly by nucleophilic addition to carbonyl compounds, or to enter into coupling reactions using a transition metal. The reactivities of each organometallic are different, offering synthetic chemists a wide range of reagents. The search for new reactivities or new reactions involving other metals is also booming (Ga, Si, Zr, Ti, etc.). The chemistry of coupling reactions has been modernized by integrating catalysis using transition metals, and in particular metals such as iron, as part of a sustainable chemistry approach. Despite specific constraints linked to the hydrosensitivity and exothermicity...