9. Co-amorphs
Amorphous polymer-based solid dispersions are widely used to stabilize amorphous materials and improve the oral bioavailability of poorly soluble PAs in the crystalline state
. However, the use of polymer-based DSA has limitations. Many polymers are hygroscopic, which can lead to high water absorption. This plasticizes the system, thereby increasing the molecular mobility of PAs and facilitating their cris-tallization
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Co-amorphs