6. Solubility/miscibility: crystal/amorphous comparison
To understand the specifics of the "dissolution" of an amorphous compound, it is necessary to compare the situation with that of a crystalline compound, by considering the possible action of a solubilizing agent and that of a situation of crystalline polymorphism.
6.1 Dissolution of a crystalline active ingredient in a solvent
Figure 13 schematically illustrates the thermodynamic situation associated with the dissolution of a crystalline PA in a solvent. In practice, this solvent is often water, but this diagram can also be used when we are interested in the dissolution of a PA in an excipient, whether polymeric or not.
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Solubility/miscibility: crystal/amorphous comparison
Advantage of amorphous state for solubility and oral absorption
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