2. Intermolecular interactions: biological affinity and free energy variation
2.1 The physical principle of affinity
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For non-covalent intermolecular interactions between two molecules, a macromolecule and a ligand, an equilibrium association constant called K eq is determined, valid at a given temperature. This constant, described in relation to the law of mass action (5) , reflects the affinity between a protein P and a ligand L :
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Intermolecular interactions: biological affinity and free energy variation
Designing new ligands
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