Suppository formulation
Suppository formulation and manufacturing

As we have already seen, suppository masses are made up of lipophilic or water-soluble products that dissolve in the rectal ampoule. The choice of one or other of these categories depends on the properties of the active ingredient chosen for the targeted therapeutic application.

The solubility of the active ingredient is generally a major criterion in the choice of suppository mass. For example, hydrophilic active ingredients can be formulated in lipophilic suppository masses, while lipophilic active ingredients can be formulated in hydrophilic masses. In both cases, the suppository enables dispersion of the active ingredient in the rectal ampoule and facilitates its release.

Most rectal active ingredients...