9. Photoallergy
It is a pathological skin mechanism following UV exposure, caused by photochemical changes due to UV rays, substances absorbed locally in the skin, or substances reaching the skin's surface via the bloodstream. The photoantigen is then taken up by T lymphocytes according to the mechanism of type IV delayed hypersensitivity reaction.
Contact photoallergy is induced by UVA (320–400 nm), regardless of the maximum absorption spectrum of the photoallergen.
9.1 Induction
The scapular area of albino guinea pigs is shaved (clipped close to the skin). The test substance, undiluted or in a suitable vehicle at an irritant concentration, is applied to the test area. The treated area is massaged to ensure that the substance...
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Photoallergy
Photo-Patch test in humans
Bibliography
A. Lombard et al. - Technical and economic evaluation of products in the early stages of development. Part 2, pp. 153-281, ISTE Publishing Ltd London (2024).
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