Frequently asked questions
Determining toxicological reference values (TRVs)

Are there VTRs for each substance?

No, only substances that are particularly hazardous and/or produced in large volumes are subject to VTR. Official bodies are unable to work on the approximately 100,000 substances on the market. This is why, under REACh, producers are required to define DNELs and DMELs, which can be used pending official VTRs.

Are VTRs harmonized at the European or international level?

It should be remembered that VTRs are part of the risk management measures implemented in each state, and that these VTRs are defined according to toxicological and epidemiological criteria, but also socio-economic criteria that take into account the industrial accident scenarios identified at the level of each state. This means that the concept of acceptable risk for a substance may vary from country to country for...