Chemical stability: coupling chemical reactivity and structural relaxation
Amorphous and glassy states of molecular and pharmaceutical compounds Applications and uses

In addition to physical stability, the crystalline state generally ensures high chemical stability of a compound. The amorphous state, on the other hand, can be a source of chemical instability. This is well demonstrated, for example, in a quantitative nuclear magnetic resonance study ( ¹³ C NMR – CPMAS spectrum evolution) of the mutarotation reaction of dry lactose . When anhydrous crystalline α-isomeric lactose (αL) is heated to melting (≈ 200°C), no mutarotation from α to β form is observed. After melting,...