5. Conclusion
This article summarizes work on the distribution of residence
times in extrusion processes over the period from 1970 to the present
day. Although the peak of publications occurred around 2000, new interest
in this subject has emerged in recent years, due to the development
of hot melt extrusion (HME) and wet granulation for pharmaceutical
applications.
Over the years, measurement techniques have evolved considerably.
From the off-line techniques of the early days, we have gradually
moved on to increasingly precise on-line measurements, enabling both
global and local measurements to be taken by placing appropriate probes
at different points along the barrel.
Although the main contributions of processing parameters to RTD
are now well understood, some questions remain unanswered, such as
the influence of rheological properties. Shear viscosity...
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