Nucleophilic organometallic reactions
Organometallic Nucleophilic Reagents in Organic Synthesis. Theory and Applications

In this reactivity section, acid-base reactions involving organometallic reagents will not be covered. These are often reactions designed to form a carbanion by attack of BuLi or LDA on activated methyls (CH ₃ ), methylenes (CH ₂ ) or, more rarely, methines (CH).

However, the nucleophilic attack of these organometallic reagents on electrophiles, leading to the formation of a new carbon-carbon bond, will be covered. These electrophiles are often, but not exclusively, carbonyl derivatives or related compounds (imines, Schiff bases, nitriles...) and, after acid hydrolysis, lead to the corresponding products, usually alcohols, whose class depends on the nature of the initial electrophile (figure