Elimination/excretion: how does our body get rid of chemicals?
ADME: circuit of a chemical substance in the body

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FIC1168 V1 Practical sheet

Elimination/excretion: how does our body get rid of chemicals?


ADME: circuit of a chemical substance in the body

Author : Alain LOMBARD

Publication date: February 10, 2025 | Lire en français

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4. Elimination/excretion: how does our body get rid of chemicals?

4.1 Elimination routes

The physico-chemical properties of the substance and its metabolites determine the route of elimination.

  • Urine: polar, water-soluble metabolites (benzene and phenol metabolites).

  • Expired air: all volatile substances (solvents, ethylene, etc.).

  • Faeces: lipophilic compounds excreted by labile (chlorinated aromatics, etc.) and inert products or undigested substances (kerosene oil, metals, etc.).

  • Sweat and skin: certain metals (lead, mercury, arsenic, etc.).

The molecular weight of metabolites determines their excretion route.

  • Low...

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