3. Immobilization procedures
The ligand can be immobilized on the solid support of the biosensor by various methods, such as adsorption, covalent coupling, encapsulation, etc. The aim of any immobilization method is to retain the maximum activity of the biological ligand on the transducer surface. The selection of an appropriate immobilization method depends on the nature of the biological ligand, the type of transducer used, the physico-chemical properties of the analyte and the operating conditions of the biosensor
Physical adsorption of a ligand based on attractive Van der Waals forces is the oldest and simplest method of immobilization. It requires no chemical modification of the ligand, and allows the biosensor to be regenerated....
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Immobilization procedures
Regeneration of biosensors
Economic data
The biosensor industry is booming. The market comprises 4 segments: medical, environmental, agri-food and military, with medical applications accounting for the vast majority (90% of sales are of glucose-detecting biosensors).
In the food industry, pathogen detection is the biggest market. In the USA, a recent study
References
Commercially available biosensors
Despite a large number of publications on biosensors applied to food analysis, only a small number of systems are commercially available. The disadvantages that need to be overcome are the limited lifetime of biological compounds, large-scale production and ease of use.
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Few biosensors are currently used in the dairy industry for on-line analysis, although...
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