6. Frequently asked questions
Are there TLVs for each substance?
No, only particularly hazardous substances and/or those produced in large volumes are subject to ELVPs. Official bodies are unable to work on the 100,000 or so substances on the market. This is why, under REACh, manufacturers are asked to define DNELs and DMELs, which can be used pending official VLEPs.
Are VLEPs harmonized at European or international level?
It should be remembered that VLEPs are part of the risk management measures implemented in each country, and that these VLEPs are defined according to toxicological and epidemiological criteria, as well as socio-economic criteria. In other words, the notion of acceptable risk for a substance may vary from country to country, for a variety of reasons.
What is the difference between VLEP and DNEL?...
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Bibliography
Also in our database
Bibliography
ECETOC: Guidance on Assessment Factors to Derive a DNEL; Technical Report N°110, 2010.
ECHA: Guidance on information requirements and chemical safety assessment Chapter R.8: Characterisation of dose [concentration]-response for human health, version 2.1, 2012.
ECHA: How to prepare toxicological summaries in IUCLID and how to derive...
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In particular, ECHA publishes a guide for characterizing concentrations in order to protect the health of exposed persons, and a guide for determining exposure to chemicals. These guides are published by ECHA, the European Chemicals Agency.
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