6. Solubility/miscibility: crystal/amorphous comparison
To understand the specifics of the "dissolution" of an amorphous compound, it is necessary to compare the situation with that of a crystalline compound, by considering the possible action of a solubilizing agent and that of a situation of crystalline polymorphism.
6.1 Dissolution of a crystalline active ingredient in a solvent
Figure 13 schematically illustrates the thermodynamic situation associated with the dissolution of a crystalline PA in a solvent. In practice, this solvent is often water, but this diagram can also be used when we are interested in the dissolution of a PA in an excipient,...
Exclusive to subscribers. 97% yet to be discovered!
Already subscribed? Log in!
Solubility/miscibility: crystal/amorphous comparison
Advantage of amorphous state for solubility and oral absorption
Article included in this offer
"Functional materials - Bio-based materials"
(
191 articles
)
Updated and enriched with articles validated by our scientific committees
A set of exclusive tools to complement the resources
Bibliography
Bibliography
Exclusive to subscribers. 97% yet to be discovered!
Already subscribed? Log in!
