4. Conclusion

Phosphocalcic cements combined with active molecules are currently very popular in bone reconstruction surgery, whether to reinforce the stability of prostheses, prevent the risk of bone infections, or prevent the recurrence of osteolytic tumors.

These systems are also being considered to enhance the osteogenic potential of conventional bone substitutes, notably by incorporating hormones and growth factors such as BMP-2. However, these proteins are fragile and could generate deleterious side effects. Targeted vectorization of their encoding DNA is one way of enabling these factors to be synthesized in situ without being degraded.

Research is also moving towards the development of a new generation of combined biomaterials in which osteoprogenitor cells would be added to these growth factors to recreate a microenvironment conducive to bone...