Frequently asked questions
ADME: circuit of a chemical substance in the body

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FIC1168 V1 Practical sheet

Frequently asked questions


ADME: circuit of a chemical substance in the body

Author : Alain LOMBARD

Publication date: February 10, 2025 | Lire en français

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8. Frequently asked questions

How do you know if a metabolite is genotoxic?

Chemical structure analyses should be used to determine which groups are at risk (see figures "Metabolism of a double bond" and "Example of styrene metabolism").

For example, all organic substances with a double bond have the ability to open this double bond first to form an epoxide. This epoxide combines with DNA in a covalent bond. This combination is genotoxic.

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