1. Home
  2. Environment - Safety
  3. Chemical risk prevention manager
  4. Usage of 1.3 dicarbonyl derivatives in domino and multicomponent reactions

  5. Enantioselective domino and multicomponent reactions

Article | REF: CHV2210 V1

Usage of 1.3 dicarbonyl derivatives in domino and multicomponent reactions

Authors: Damien BONNE, Thierry CONSTANTIEUX, Yoann COQUEREL, Jean RODRIGUEZ

Publication date: May 10, 2010, Review date: October 17, 2017 | Lire en français

You do not have access to this resource.
Click here to request your free trial access!

Already subscribed? Log in!

Automatically translated using artificial intelligence technology (Note that only the original version is binding) > find out more.

    A  |  A

    2. Enantioselective domino and multicomponent reactions

    In recent years, the growing interest of pharmaceutical and agrochemical companies in the production of enantiopure molecules, i.e. in a single enantiomeric form, has led to an unprecedented demand for new enantioselective synthesis methods. The two enantiomers of a chiral molecule (a drug, for example) can have different physiological effects.

    An infamous example is thalidomide (figure 31 ), a drug marketed in the 1950s whose right-hand form has sedative properties, while the left-hand form causes congenital malformations.

    Similarly, the two enantiomers of limonene have different olfactory responses (figure 31 ).

    ...
    You do not have access to this resource.

    Exclusive to subscribers. 97% yet to be discovered!

    You do not have access to this resource.
    Click here to request your free trial access!

    Already subscribed? Log in!

    The Ultimate Scientific and Technical Reference

    A Comprehensive Knowledge Base, with over 1,200 authors and 100 scientific advisors
    + More than 10,000 articles and 1,000 how-to sheets, over 800 new or updated articles every year
    From design to prototyping, right through to industrialization, the reference for securing the development of your industrial projects

    This article is included in

    Chemical risk prevention manager

    This offer includes:

    Knowledge Base

    Updated and enriched with articles validated by our scientific committees

    Services

    A set of exclusive tools to complement the resources

    Practical Path

    Operational and didactic, to guarantee the acquisition of transversal skills

    Doc & Quiz

    Interactive articles with quizzes, for constructive reading

    Subscribe now!

    Ongoing reading
    Enantioselective domino and multicomponent reactions
    Outline