Enantioselective domino and multicomponent reactions
Usage of 1.3 dicarbonyl derivatives in domino and multicomponent reactions
Article REF: CHV2210 V1
Enantioselective domino and multicomponent reactions
Usage of 1.3 dicarbonyl derivatives in domino and multicomponent reactions

Authors : Damien BONNE, Thierry CONSTANTIEUX, Yoann COQUEREL, Jean RODRIGUEZ

Publication date: May 10, 2010, Review date: October 17, 2017 | Lire en français

Logo Techniques de l'Ingenieur You do not have access to this resource.
Request your free trial access! Free trial

Already subscribed?

2. Enantioselective domino and multicomponent reactions

In recent years, the growing interest of pharmaceutical and agrochemical companies in the production of enantiopure molecules, i.e. in a single enantiomeric form, has led to an unprecedented demand for new enantioselective synthesis methods. The two enantiomers of a chiral molecule (a drug, for example) can have different physiological effects.

An infamous example is thalidomide (figure 31 ), a drug marketed in the 1950s whose right-hand form has sedative properties, while the left-hand form causes congenital malformations.

Similarly, the two enantiomers of limonene have different olfactory responses (figure 31 ).

...
You do not have access to this resource.
Logo Techniques de l'Ingenieur

Exclusive to subscribers. 97% yet to be discovered!

You do not have access to this resource. Click here to request your free trial access!

Already subscribed?

Ongoing reading
Enantioselective domino and multicomponent reactions

Article included in this offer

"Chemical risk prevention manager"

( 219 articles )

Complete knowledge base

Updated and enriched with articles validated by our scientific committees

Services

A set of exclusive tools to complement the resources

View offer details
Contact us
Contact our team FAQ