3. Solid-state versus homogeneous-phase synthesis
3.1 Solid-state synthesis
Through its historical application to peptide synthesis, combinatorial chemistry is closely linked to solid-state synthesis. This enables the production of very pure molecules with complex multi-step synthesis protocols.
SCROLL TO TOPOne of the monomers is covalently attached (possibly via a linker arm) to the reactive sites of an insoluble material, the solid support (figure 6). This may be a glass or polymer support,...
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Solid-state versus homogeneous-phase synthesis
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