4. Model building and evaluation
Model building in a pharmacometrics analysis requires proposed models to be evaluated, and compared statistically. In this section, we present the inference and diagnostic tools used to conduct this decision-making process .
4.1 Inference
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Maximum likelihood inference
In regression, the classic inference tests are the likelihood ratio test (LRT), the Wald test and the score test. In MNLEM, the LRT, Wald test and statistical criteria such...
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Model building and evaluation
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