11. Other preferred chemical structures
Some structural motifs are only found in a single therapeutic class, and are the vectors of a very specific pharmacological activity. This is the case for several families of antibiotics, non-steroidal anti-inflammatories, local anesthetics, bone resorption inhibitors, calcium antagonists and alkylating antitumor agents.
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Beta-lactams are antibiotic substances with a β-lactam nucleus (figure
22
), grouped into two families: penicillins and cephalosporins.
The first compounds of natural origin, which could only be...
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Other preferred chemical structures
Bibliography
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(1) - KINSELLA (G.K.), ROZAS (I.), WATSON (G.W.) -
Modelling the interaction of catecholamines with the α1A adrenoceptor towards a ligand-induced receptor structure.
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Journal of computer aided molecular design, 19(6), p. 357-367 (2005).
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(2)...
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