2. How is a DNEL established?
First, the toxicological profile of the substance must be established and all relevant data collected. Next, the most relevant and valid studies must be selected (Klimisch, see Criteria for determining the rating of a study (Tool
1
)).
It is also necessary to determine the modes of action (MoA) of the substance and identify the effects observed on cells and organs (effects with or without a threshold).
...
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How is a DNEL established?
How can a DNEL be derived in practice?
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