Determining DNELs

Manufacturers and importers of chemicals must assess the potential toxic effects of these substances on humans in order to comply with ECHA rules under the European REACH regulation.

They must set DNELs to protect workers, consumers, and the general population, as well as subpopulations potentially exposed to the chemical.

DNELs are calculated values specific to a substance that take into account the duration, frequency, and route of exposure, as well as the subpopulation potentially exposed. Calculating DNELs for chemical substances is an important process that requires significant commitment from manufacturers to protect workers and consumers. This delicate calculation must be based on a relevant analysis of existing toxicological data.

This fact sheet will help you understand how DNELs are calculated and defined, as well as their impact on the substance to which they apply.