4. Granular tensegrity approach

However, the approach described above needs to be supplemented by information derived from experimental observations, to guide the evolution of models towards realistic cytoskeletal architectures. It has therefore led to the development of another, more original model, which overcomes the problems linked to the specificity of each cell and, to go even further, takes into account dynamic processes such as the polymerization/depolymerization of cytoskeleton filaments, as well as their variable connectivity over time.

To this end, a coupling between cellular tensegrity approaches and theoretical and numerical tools specific to discrete media mechanics has been proposed, the latter enabling dynamic interaction processes to be modeled. The idea is to determine a model for which the geometry of the structure is not chosen a priori, but is derived from a simulation of...