8. Frequently asked questions
How do you know if a metabolite is genotoxic?
Chemical structure analyses should be used to determine which groups are at risk (see figures "Metabolism of a double bond" and "Example of styrene metabolism").
For example, all organic substances with a double bond have the ability to open this double bond first to form an epoxide. This epoxide combines with DNA in a covalent bond. This combination is genotoxic.
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Bibliography
A. Lombard et al. – Techno-economic evaluation of products in the early stages of development. Part 2, pp. 153-281. ISTE Éditions, Ltd London (2024).
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