2. How do you establish a VTR?
This method of calculating VTRs does not apply to substances without thresholds, such as mutagens, genotoxic carcinogens, and endocrine disruptors.
First, the toxicological profile of the substance must be established and all relevant data collected, then the most relevant and valid studies must be selected (Klimisch), see Determination of Derived No-Effect Levels (DNELs)
Relevant physicochemical data must also be collected by inhalation, in particular the form (gas or particles) and volatility...
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How do you establish a VTR?
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