4. Expression of toxic hazard

DANGER = static notion of potentiality

Intrinsic property of a chemical substance, set of physical and toxicological characteristics presenting a potential hazard.

RISK = dynamic notion of contingency

All the circumstances that allow the expression of a potential danger.

RISQUE = DANGER \times EXPOSITION

For some substances identified as endocrine disruptors and/or genotoxic, the dose/intensity relationship is not directly applicable. A single exposure to a low dose may be enough to trigger deleterious biological effects.

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Bibliography

(1) - ECHA Practical Guide 14 - . – How to prepare toxicological summaries in IUCLID and how to derive DNELs (2012).
(2) - INSERM - Effets chromosomiques, génétiques et épigénétiques. - Chap. 28, pp 299-307 –

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