Acute toxicity
Mixture : CLP additivity rules for health hazards
Practical sheet REF: FIC0740 V1
Acute toxicity
Mixture : CLP additivity rules for health hazards

Author : Gautier VINCENT

Publication date: October 10, 2018, Review date: August 1, 2025 | Lire en français

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1. Acute toxicity

Acute toxicity is presented in Annex I of CLP part 3.1. It concerns three pathways:

  • ingestion: the chemical enters the body through the digestive tract;

  • inhalation: the chemical enters the body via the respiratory tract; the substance can be inhaled in various forms (vapors, aerosols, etc.);

  • cutaneous: the chemical enters the body through the skin.

Important

Each route must be considered independently. A product may be toxic for one route and non-toxic for another.

For example, if you swallow viper venom, you risk nothing because the venom proteins are broken down in the stomach, whereas in the event of a bite, you need to act quickly.

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