Hydrodynamics and material transfer in cytocultivators
Processes of mass cultivation of animal cells
Article REF: BIO6800 V1
Hydrodynamics and material transfer in cytocultivators
Processes of mass cultivation of animal cells

Authors : Annie MARC, Éric OLMOS

Publication date: November 10, 2010, Review date: September 1, 2015 | Lire en français

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5. Hydrodynamics and material transfer in cytocultivators

5.1 Hydrodynamics

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5.1.1 Macroscopic approach

The hydrodynamics of cytocultivators are broadly similar to those of gas-liquid stirred reactors, but with "gentle" stirring and aeration conditions. Agitation should ensure proper suspension of cells or microcarriers, homogenization of the liquid phase to limit any concentration gradients, reduced mixing times and increased material transfer capacities (O 2 and nutrients). However, as animal cells are reputed to be fragile,...

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