How do you establish a DNEL?
Determining DNELs

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FIC1182 V1 Practical sheet

How do you establish a DNEL?


Determining DNELs

Author : Alain LOMBARD

Publication date: February 10, 2015, Review date: September 1, 2025 | Lire en français

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2. How do you establish a DNEL?

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Criteria for determining the rating of a study. Adapted from Klimisch et al (1997) and Rosner (1994)

It is also necessary to determine the substance's modes of action (MoA) and identify the effects observed on cells and organs (threshold and non-threshold effects).

Finally,...

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