3. Postfunctionalization: development of Sonogashira coupling in micellar medium

In collaboration with Dr. Fabrice Gallou's team at Novartis Pharma in Switzerland, a compound derived from the coupling of (+)-limonene and p-bromostyrene was prepared (figure 16 ) under optimized conditions. Based on this functionalized derivative and applying the developed method, a Sonogashira coupling reaction in micellar medium was developed [J 1 190] . Performing catalytic transformations in micelles offers several advantages. The first is the use of water as the main solvent, which is attractive for both economic and environmental reasons. The second concerns the quantity of catalyst introduced, since the reaction takes place in a confined environment within the micelle,...