5. Methods for characterizing endocrine disruptors
All available information on a chemical substance is used to characterize its endocrine disrupting potential, from the study of chemical formulations to tests on whole organisms.
5.1 In silico or crystallographic methods
They involve the study of structure-activity relationships (QSAR) and the modeling of ligand-receptor binding.
The QSAR (Quantitative Structure Activity Relationship) method is the establishment of a quantitative relationship between a chemical structure and an activity in the form of chemical reactivity or biological activity (for example, the presence of benzene rings with an HO function in the chemical structure, as in the case of estradiol shown in figure
The Ultimate Scientific and Technical Reference
This article is included in
Drugs and pharmaceuticals
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
Methods for characterizing endocrine disruptors
Epidemiology
Bibliography
Bibliography
- (1) - U.S. ENVIRONMENTAL PROTECTION AGENCY - Androgen receptor binding (rat ventral prostate cytosol) - (2011). https://www.epa.gov/sites/default/files/2015-07/documents/final_890.1150_ar_bindng_...
Websites
Anses https://www.anses.fr/fr/content/travaux-et-implication-de-lanses-sur-les-perturbateurs-endocriniens
INERIS https://www.inrs.fr/risques/perturbateurs-endocriniens/ce-qu-il-faut-...
Regulations
France
Law no. 2012-1442 of December 24, 2012 aimed at suspending the manufacture, import, export and marketing of any food packaging containing bisphenol A.
Law no. 2020-105 of February 10, 2020 on the fight against waste and the circular economy, known as "AGEC".
Order of September 28, 2023 setting the list of substances presenting endocrine disrupting properties...
The Ultimate Scientific and Technical Reference
