The latest publications in this offer are:
Ophthalmic preparations developed for therapeutic are available as solution, emulsion, suspension, powder, ointment, gel or insert. For safely administration some properties must be respected i.e. sterility, physico-chemical stability and local tolerancy. In this article, each preparation type is fully described in this article including formulation strategy, preparation, packaging and specific pharmacopeia tests are given. Injectable forms used intraocularly are also presented. Finally, the article also provides an overview of developments and innovations in galenic formulations, administration devices and new therapies for ophthalmology.
Unicellular or multicellular organisms have enzymatic proteins, that catalyze various specific biochemical reactions. This article is focused on the enzymatic catalysis. The active site of Chymotrypsin, Ribonuclease and Phosphotriose isomerase involved in chemical reactions are studied. The effects of physicochemical parameters (activation energy, temperature and pH) that can modulate the catalytic activity are also analyzed. Last paragraphs are dedicated to various enzyme kinetics, coenzymes, activation pathways of human enzymes and isoenzymes.
This article is devoted to functional enzymology. It succinctly describes the main enzymes allowing the functioning of eukaryotic cells constituting the most studied multicellular organisms in biology.The role of each enzyme listed is briefly mentioned in order to understand its place in the development and in the life of the entity that produced it. In this context, enzymes are described here according to their localization in cell or cellular types allowing their synthesis.
This article presents several examples of applications of nuclear magnetic resonance (NMR) spectroscopy as an analytical tool for characterising illegal health products. Some general considerations for a better understanding of the potential offered by the method are set out in the first section. The second section is devoted to the detection of adulteration in food supplements, a practice consisting in the fraudulent addition by the manufacturer of a substance with a potential therapeutic effect in a preparation advertised as natural. The third section endeavours to show the utility of NMR for the analysis of medicines, genuine or forged.
Microfluidics is increasingly used in a wide range of fields: healthcare is no exception. In this article, the contribution of microfluidics will be illustrated and discussed throughout the various stages of drug design, from active ingredient discovery to formulation. The benefits of microfluidics in diagnostic applications will also be presented. A critical review of the current state of the art will point to future development avenues addressed by academic and industrial researchers, as well as the technological hurdles to be overcome in the years ahead.
Understanding how enzymes work requires the knowledge of the stereoelectronic structure of these macromolecules formed from the assembly of amino acids espacially through the evolution of weak bonds. Various biochemical and physicochemical techniques used to determine their different levels of structure from primary to quaternary are discussed. Finally, the article includes the study of three enzymes with different structural characteristics: carbonic anhydrase, glycogen phosphorylase and human immunodeficiency virus (HIV) protease.
Very numerous classes of drugs arise from chemical families having a common structural pattern. According to the substitutions made on this basic skeleton, the synthesized molecule will have an affinity for such or such receptor or enzyme. The sequential analysis of these privileged structures (sulfonamides, azole derivatives, steroids, polycyclic systems, purine and pyrimidine bases…) allows to approach on this article most of the armamentarium at the disposal of the medical profession: antalgics, antibiotics, antihypertensive drugs, psychotropic drugs, antineoplastic agents, hormonal treatments….
High performance liquid chromatography (HPLC) is an analytical technique suitable for a large variety of applications. Some innovative solutions, in terms of stationary phases and instrumentation, were introduced to improve productivity. In parallel, some alternative strategies allowing severe modifications of selectivity and retention were also developed. Finally, this approach was also adapted for the characterisation of therapeutic proteins, which is currently a hot topic in the pharmaceutical industry
Living organisms and acellular ones have many enzymes that catalyze biochemical reactions. This article presents the main enzymatic deficits, over expressions or mutations leading to physiological modifications or dysfunctions. The evolutionary modifications occurring at the viral and bacterial levels are first recalled. The main part of the article examines pathologies associated with human enzymes. These diseases are classified into metabolic, structural, informational and cancer pathologies. The last part briefly develops the life of a virus by focusing on its enzymes. The concept of enzymatome is posed.
The aim of medicinal (or therapeutic) chemistry is to discover and develop new active principles and therefore new medicinal products. This article concisely presents the various techniques used for this purpose in medicinal chemistry. Structure-activity relationships (SAR), precursors and metabolites, research initiated by the knowledge acquired on enzyme receptors and inhibitors, quantitative relationships between structure and activity, stereoisometry, or else the physico-chemical modifications of a medicinal product are many of the elements and notable examples which allow for the illustration of these techniques.
Access to a comprehensive database of articles
Rely on the ultimate technical and scientific knowledge database
Contents written and validated by leading experts to ensure reliability and expertise
Our experts committeeQuizzes, medias, tables, formulas, videos, practical paths, etc...
Enhanced reading experience
Reference articles available in English and French
Updates available in both languages
|
Single-user
1479 € excl. VAT
|
||
| Knowledge database | ||
| Number of licenses | Depending on company size | 1 |
| Languages | French and/or English | French and/or English |
| Access to enhanced reference articles | Unlimited | Unlimited |
| Access to archives | ||
| Publication updates and monitoring tools | ||
