2. Effects on the colonic mucosa

Brain axis – intestine – microbiota

Over the past few years, the role of intestinal microorganisms has attracted a great deal of attention, but now for pathologies that go beyond the classic infectious diseases. The current focus is on dysbiotic modifications of the intestinal flora and their metabolic impact, leading to a wide range of pathologies such as diabetes, obesity, certain cardiovascular diseases, as well as cancers (particularly colorectal) and certain neurodegenerative diseases...

Following the numerous studies published to date, the concept of a bidirectional brain-gut axis has been accepted, but some consider it more appropriate to differentiate between the gut and its microbiome, leading to three channels: brain – gut – microbiome interacting with each other via nervous, endocrine and immune mechanisms...