2. Intermolecular interactions: biological affinity and free energy variation

2.1 The physical principle of affinity

For non-covalent intermolecular interactions between two molecules, a macromolecule and a ligand, an equilibrium association constant called K _eq is determined, valid at a given temperature. This constant, described in relation to the law of mass action (5) , reflects the affinity between a protein P and a ligand L :
$K_{eq} = [PL] / [P] [L]$

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Intermolecular interactions: biological affinity and free energy variation

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(1) - LEACH (A.) - Molecular modelling : principles and applications. - (2 ^nd edition) Prentice Hall (2001).
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