2. Multi-component reactions and green chemistry
As mentioned in the introduction, multicomponent reactions are perfectly suited to the criteria of environmental protection. Indeed, they satisfy many of the principles of green chemistry.
2.1 Saving steps
Conventional molecule synthesis routes create a single bond per step. This approach is very costly in terms of solvents, auxiliary reagents, energy and time. Multi-component reactions, on the other hand, create several bonds in a single operation in the same reaction medium, without purification of intermediates. They are therefore clean reactions in that the use of solvents is limited to the reaction itself. As intermediates are not isolated, purification steps, which consume large quantities of organic solvents, are limited, which also reduces the cost...
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Multi-component reactions and green chemistry
Multi-component and organometallic reactions
Bibliography
Other works
ISAMBERT (N.) and LAVILLA (R.) – Heterocycles as key substrates in multicomponent reactions: the fast lane toward molecular complexity. Chem. Eur. J., 14, p. 8444-8454 (2008).
ULACZYK-LESANLO (A.) and HALL (D.G.) – New multicomponent reactions for generating libraries of polycyclic natural products. Curr. Opin. Chem. Biol. 9, pp. 266-276 (2005).
GANEM (B.) – Strategies for...
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