Impregnation processes
Forming processes of pharmaceutical active principles in supercritical phase
Article REF: CHV4010 V1
Impregnation processes
Forming processes of pharmaceutical active principles in supercritical phase

Author : Elisabeth BADENS

Publication date: September 10, 2017, Review date: December 5, 2016 | Lire en français

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4. Impregnation processes

4.1 General features of supercritical impregnation

Supercritical fluids are vectors/impregnating agents of choice because of their specific properties described above: a liquid-like density (200 to 900 kg · m –3 ), a gas-like viscosity (10 –5 to 9 × 10 –5  Pa · s), a diffusivity higher than in liquid phase (2 × 10 –8 to 7 × 10 –8  m 2  · s –1 ) and a very low interfacial tension. The transport of a solute, solubilized in a supercritical phase, inside a solid matrix is...

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