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Article | REF: SL270 V1

Immunological dosages: modeling and statistical inference

Author: Sylvie HUET

Publication date: December 10, 2008, Review date: January 11, 2019 | Lire en français

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    1. Observation modeling and curve estimation

    Statistical analysis of immunoassay data involves modeling and estimating the parameters of a curve in a regression model. For this reason, the regression model and methods for estimating parameters are described in this first paragraph.

    1.1 Estimation of a calibration curve. Interferon gamma assay

    Interferon-gamma assays are used to diagnose patients suffering from severe mutations that seriously disrupt the functioning of their immune system. . Quantifying the gamma interferon contained in a plasma sample requires a two-step procedure:

    • establish a calibration curve from a standard solution;

    • invert the curve to determine the unknown dose of gamma interferon contained...

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