8. Conclusion
The accuracy profile methodology has already been applied in a large number of applications (see the non-exhaustive list in the Need to know more section).
A number of conclusions can be drawn from these examples.
The great generality of this approach. The list of methods that have been studied is already long: chromatography, spectroscopy, titrimetry, gravimetry, ELISA, PCR, microbiology, physics and so on.
In very general terms, if we take the definition of validation, the proposed approach follows exactly this definition: 1) start from the objectives to be achieved in terms of acceptability limits; 2) collect actual evidence through experimental designs; 3) then examine it statistically and graphically to confirm or invalidate validity.
The level-by-level profile...
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Conclusion
Bibliography
Software tools
There are few software packages dedicated to method validation. Arlenda ( http://www.arlenda.com/ ) has developed one called "e-noval®". It uses the accuracy profile and produces a certified report. Its originality lies in the fact that it operates via the Internet (Web-based solution): the user copies the data into an Internet interface,...
Websites
AOAC (Association of Official Analytical Chemists): originally American, this association of analysts has become international. In addition to its standardizing role, it validates methods according to various protocols http://www.aoac.org/
EURACHEM, a network of European organizations whose aim is to set up a forum for the traceability...
Standards and norms
Association française de normalisation Afnor
- Water quality – Protocol for initial assessment of method performance in a laboratory - NF T90-210 - 2009
- Exigences générales concernant la compétence des laboratoires d'étalonnages et d'essais - NF EN ISO/CEI 17025 - 2005
- Laboratoires d'analyses de biologie médicale....
International Organization for standardization ISO
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