4. How can the effects of chemical substances be determined?
These effects are determined on the basis of the action point or duration of exposure.
4.1 Action point
Local : results from a harmful action localized at the point of contact (skin, eye, respiratory tract).
Systemic, resulting from penetration and distribution in the body (target organs: liver, kidneys, blood, etc.).
4.2 Exposure time
Exposure can be of two kinds.
Exposure may be the result of accidental, time-limited contact with high doses, leading to...
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How can the effects of chemical substances be determined?
What are the degrees of severity?
Bibliography
A. Faqi, A Comprehensive Guide to Toxicology in Preclinical Drug Development , Elsevier editions (2012).
Klimisch H., Andreae M. and Tillmann U., A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data (1997).
R. Lauwerys, V. Haufroid, P. Hoet, D. Lison. Toxicologie industrielle et intoxications professionnelles , éditions Masson;...
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