7. Frequently asked questions
How can I check the information in the MSDS?
The information is contained in chapter 11 – Toxicology in the paragraphs "Specific Target Organ Toxicity" or STOT.
How can information contained in the SDS be verified in the REACh dossier?
The detailed description of toxicology studies includes the results of biochemical and histological analyses, for example in the carcinogenesis study on methylene chloride: inhalation doses in three groups: 0, 2,000 and 4,000 ppm.
Kidneys: the incidence of morphological changes in renal tubules is increased between control and test animals: in male mice: control (6/50, 12%), low dose (11/49, 22%), high dose (20/50, 40%) in female mice: control (8/49, 16%); low dose (23/48, 48%); high dose (23/47, 49%).
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Bibliography
Also in our database
Bibliography
Setal. J. Exposure to organic solvents. Risk of progression of chronic kidney disease to end-stage renal disease. DMT, 2008, 114,233-41.
Lauwerys. R. Toxicologie industrielle et intoxications professionnelles. Masson, 5th ed. 2007.
Stengel. B. Renal diseases of occupational toxic origin. Encycl. Surgical Medicine, Toxicology, 16-530-H-10,...
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